To do this, scientists decided to use the drug targetin (becoxorotene), which showed high efficiency in the treatment of Cutaneous T cutaneous T lymphoma, a type of cancer of the immune system. Researchers needed to adapt it to fight other tumors.
However, filling the nanobubbles with the drug is not enough. It was necessary to achieve that they would “work” in time in the tumor. At the stage of the experiments, the vesicles were introduced into the liver of the pig using a flexible catheter. After the bubbles were in the right place, they were initiated by ultrasound – they burst, releasing the drug.
On the results of the experiment, the leading researcher of the University Dipanyan Pan said:
“The study of the mechanism of screening drugs on the liver of a pig will help us in time to adapt a new method of treatment to humans.”